- Jerome Williams will make his first start in over a month for the Phillies after being activated from the disabled list on Monday night. Williams has underwhelmed in production this year compared to last as he is 3-7 with a 6.43 ERA in 14 starts. Williams was 4-2 with a 2.83 ERA in nine starts for the Phillies in 2014.
- Rookie third baseman Maikel Franco was out of the Phillies' lineup Tuesday and Wednesday with elbow soreness. Phillies interim manager Pete Mackanin indicated Tuesday that it is likely the rookie will return to the lineup Friday.
- If the rest of the season is any indication, this likely won't be a series where starters provide many innings. The Phillies and Cubs have combined to pitch 606 innings from the bullpen this year, an average of just under 3 1/3 innings per game. The two teams are second and fifth, respectively, in the NL in bullpen innings.